Diminished ovarian reserve in the United States assisted reproductive technology population: diagnostic trends among 181,536 cycles from the Society for Assisted Reproductive Technology Clinic Outcomes Reporting System

OBJECTIVE:

To evaluate trends in diminished ovarian reserve (DOR) assignment in the Society for Assisted Reproductive Technology (SART) Clinic Outcomes Reporting System database and to evaluate its accuracy in predicting poor ovarian response (POR) as defined in European Society of Human Reproduction and Embryology’s Bologna criteria (2011).

DESIGN:

Retrospective cohort study.

MAIN OUTCOME MEASURE(S):

DOR assignment was the primary exposure.

…

Read More

Baby budgeting: oocyte cryopreservation in women delaying reproduction can reduce cost per live birth

OBJECTIVE:

To determine whether oocyte cryopreservation for deferred reproduction is cost effective per live birth using a model constructed from observed clinical practice.

DESIGN:

Decision-tree mathematical model with sensitivity analyses.

MAIN OUTCOME MEASURE(S):

Cost per live birth.

RESULT(S):

Our primary model predicted that oocyte cryopreservation at age 35 years by women planning to defer pregnancy attempts until age 40 years would decrease cost per live birth from $55,060 to $39,946 (and increase the odds of live birth from 42% to 62% by the end of the model),

…

Read More

Carrier Screening With Next-Generation Sequencing Detects Common, Uncommon, and Novel Mutations

OBJECTIVE:

Our objective was to evaluate the clinical effectiveness of NGS in screening for carriers of 14 society-recommended disorders across a large number of patients in a clinical setting.

DESIGN:

Using NGS, we evaluated carrier status for up to 14 diseases (as ordered by physicians) for 71,070 patients from IVF centers across the US.

…

Read More

Timing luteal support in assisted reproductive technology: a systematic review

OBJECTIVE:

To summarize the available published randomized controlled trial data regarding timing of P supplementation during the luteal phase of patients undergoing assisted reproductive technology (ART).

DESIGN:

A systematic review.

INTERVENTION(S):

Different starting times of P for luteal support.

MAIN OUTCOME MEASURE(S):

Clinical pregnancy (PR) and live birth rates.

…

Read More

Carrier Screening for Spinal Muscular Atrophy Among U.S. In Vitro Fertilization Patients

Carrier Screening for Spinal Muscular Atrophy Among U.S. In Vitro Fertilization Patients

Kaylen Silverberg MD1, Jocelyn Davie MS2, Nicole Faulkner PhD2, Valerie Greger PhD2, Dana Neitzel MS2
1 Texas Fertility Center, Austin TX USA 2Good Start Genetics®, Inc., Cambridge, MA, USA

Background: Spinal muscular atrophy (SMA) is a recessive neuromuscular disorder that typically causes severe muscle weakness,

…

Read More

Comparison of two simulation systems to support robotic-assisted surgical training: a pilot study (swine model).

OBJECTIVE:

To compare the efficacy of simulation-based training between the Mimic dV- Trainer and traditional dry lab da Vinci robot training.

DESIGN:

A prospective randomized study analyzing the performance of 20 robotics-naive participants. Participants were enrolled in an online da Vinci Intuitive Surgical didactic training module, followed by training in use of the da Vinci standard surgical robot.

…

Read More