Purpose of the Study and Background

SiD, an assistant for sperm selection during intracytoplasmic sperm injection in medically assisted reproduction: effect on fertilization, blastocyst formation, early pregnancy loss, and consistent practice. A prospective pilot study.

Main objective

To prospectively evaluate the impact of sperm selection for standard Intracytoplasmic Sperm Injection (ICSI) on performance indicators such as the oocyte fertilization rate, blastocyst formation and development and early pregnancy loss, using an artificial intelligence trained recognition program which identifies specific sperm characteristics previously shown to be beneficial for optimal fertilization and embryo development (SiD software).

Secondary objectives

1. Correlate SiD’s recommendations on a retrospective control video database with successful treatments.
2. Evaluate the generalizability of the SiD prediction model.
3. Evaluate the usability of the SiD system within the workflow of an IVF laboratory
4. Analyze the association between different types of sperm movement and the success of the procedure.
5. Evaluate the difference in blastocyst quality by using SiD through embryo assessment AI technologies.