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Preimplantation Genetic Testing, PGT-A

Preimplantation genetic testing for aneuploidy can detect abnormal chromosomes in embryos

Many patients who pursue IVF decide to include preimplantation genetic testing for aneuploidy, or PGT-A, with their cycle. This technique can increase the likelihood of your Austin fertility doctor transferring a chromosomally normal embryo to the uterus. Texas Fertility Center works closely with Ovation® Fertility, our partner IVF lab, as well as the leading genetics labs in the country. This collaboration allows us to offer this advanced fertility treatment to our patients.

What types of patients are good candidates for PGT-A?

We all have 22 pairs of chromosomes and one pair of sex chromosomes (X and Y). When the sperm fertilizes an egg, the mother contributes one chromosome to each of the embryo’s pairs. The father will then provide the complementary chromosome. However, this process isn’t always perfect.

Problems can occur when an embryo has an extra or a missing chromosome. This is called aneuploidy. Another issue that can occur is translocation. This is when part of one chromosome breaks off and reattaches in a different place on another chromosome. These issues can lead to problems like IVF cycle failure, miscarriages and birth defects.

Certain groups of patients are more likely to experience these issues. As a result, the following groups of patients can benefit from preimplantation genetic testing for aneuploidy.

PGT-A is also a great option for anyone who wants to improve their chance of having a healthy pregnancy and baby.

How does preimplantation genetic testing for aneuploidy work?

When a couple decides to have PGT-A, they undergo an IVF cycle. After fertilizing the embryos and allowing them to grow in the laboratory, the embryologist will take a small sample of six to eight cells from each embryo. This will occur on Day 5, 6 or 7 following the egg retrieval.

There are several embryo biopsy techniques available. However, we believe that using a laser allows us to take the best-quality sample with the least risk of damage to the embryo. After the biopsy, the embryologist freezes the embryos and sends the samples to a genetics laboratory. A patient’s Austin fertility doctor will typically receive the results within seven to 10 days.

Using the results of the PGT-A report, the doctor will transfer one chromosomally normal embryo to the uterus. The next step is monitoring the patient for signs of pregnancy over the coming days.

To learn more about preimplantation genetic testing for aneuploidy, contact us to schedule an appointment. Our team of fertility experts is here to help you have a healthy baby.