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Patient experience in a randomized trial of a weekly progesterone vaginal ring versus a daily progesterone gel for luteal support after in vitro fertilization

Patient experience in a randomized trial of a weekly progesterone vaginal ring versus a daily progesterone gel for luteal support after in vitro fertilization

Objective:

To assess patient experience and convenience of using progesterone vaginal ring (VR) versus vaginal gel for women requiring luteal phase support during in vitro fertilization (IVF).

Design:

Post hoc analysis of a prospective, randomized, single-blind, multicenter, phase 3 clinical trial.

Setting:

Twenty-two U.S. IVF centers.

Patient(s):

Women undergoing IVF (N = 1,297).

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High FSH dosing is associated with reduced live birth rate in fresh but not subsequent frozen embryo transfers

High FSH dosing is associated with reduced live birth rate in fresh but not subsequent frozen embryo transfers

STUDY QUESTION:

Do live birth rates (LBRs) differ between fresh embryo transfer (fresh ET) cycles and their subsequent paired frozen ET (FET) cycles, when comparing cycles based on the total FSH dose used during the fresh cycle?

SUMMARY ANSWER:

When compared to the paired frozen embryo transfer cycles, the LBR in the fresh cycle of the highest total FSH dose group (>2500 IU) was reduced by 38%.

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Stress relief: can continuous culture in a low lactate culture media reduce numerical chromosomal abnormalities and therefore improve euploidy rates?

Stress relief: can continuous culture in a low lactate culture media reduce numerical chromosomal abnormalities and therefore improve euploidy rates?

OBJECTIVE:

To compare PGT-A results from embryos cultured in a new formulation of culture media against those embryos cultured in a sequential or single-step culture system.

DESIGN:

Retrospective analysis in private reproductive technology programs.

MATERIALS AND METHODS:

From 2016 – 2018, embryos in two separate IVF laboratories (Lab A & B) were either cultured to the blastocyst stage in a sequential culture system (G-Series™,

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Prospective observational, comparative and validation study using a timelapse morphometry miri® imaging incubator

Prospective observational, comparative and validation study using a timelapse morphometry miri® imaging incubator

Objective:

To compare blastulation rates and pregnancy success from embryos cultured in standard “large-box” Sanyo incubators and Miri® TL Benchtop Multi-room Incubators.

Design:

An IRB approved prospective observation and validation study in a private reproductive technology program.

Materials and Methods:

A total of 65 patients consented and were enrolled into the Time-lapse Morphometry Miri® Imaging Incubator (TiMMI) study.

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Ploidy variation in trophectoderm biopsies from day 5, 6, and 7 blastocysts

Ploidy variation in trophectoderm biopsies from day 5, 6, and 7 blastocysts

OBJECTIVE:

To compare ploidy rates amongst day 5, 6, and 7 blastocysts.

DESIGN:

Retrospective study in a private in vitro fertilization laboratory.

AIM:

Some data suggests that Day 7 (D7) blastocysts can give rise to nearly 27% ongoing pregnancy success by frozen embryo transfer (Kovalevzky et al., 2013). We chose to compare the aneuploidy rate observed amongst day 5,

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Live birth and multiple birth rates in women under age 38 by elective single embryo transfer (ESET) versus double embryo transfer (DET) in United States IVF clinics

Live birth and multiple birth rates in women under age 38 by elective single embryo transfer (ESET) versus double embryo transfer (DET) in United States IVF clinics

OBJECTIVE:

To compare live birth and multiple birth rates for cycles using eSET versus DET among women under age 38.

DESIGN:

Retrospective cohort study.

MATERIALS AND METHODS:

Data were collected on all autologous fresh IVF cycles performed in 2013 and reported to the National Assisted Reproductive Technology Surveillance System (NASS). Cycles using preimplantation genetic diagnosis or screening were excluded.

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Elective single embryo transfer in women under age 38 reduces multiple birth rates but not live birth rates in United States fertility clinics

Elective single embryo transfer in women under age 38 reduces multiple birth rates but not live birth rates in United States fertility clinics

OBJECTIVE:

To determine the effect of elective single embryo transfer (eSET) rates on live birth rates and multiple birth rates in United States IVF clinics.

DESIGN:

Retrospective cohort study.

MATERIALS AND METHODS:

Data were collected on all autologous fresh IVF cycles performed in 2013 and reported to the National Assisted Reproductive Technology Surveillance System (NASS).

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A comparison of pregnancy rates of frozen embryo transfers of vitrified blastocysts to vitrified euploid blastocysts

A comparison of pregnancy rates of frozen embryo transfers of vitrified blastocysts to vitrified euploid blastocysts

OBJECTIVE:

To compare the pregnancy rates of frozen (vitrified) blastocyst transfers to the transfers of vitrified euploid blastocysts.

DESIGN:

Retrospective study in a private assisted reproductive technology program.

MATERIALS AND METHODS:

Pregnancy rates for transfer of vitrified blastocysts were compared with those of euploid vitrified blastocysts in a total of 448 embryo transfer cycles.

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Regional differences in elective single embryo transfer: is location everything?

Regional differences in elective single embryo transfer: is location everything?

OBJECTIVE:

Previous studies suggested significant regional differences in access to United States IVF centers(1), and some suggested that limited access is associated with patient decisions regarding number of embryos to transfer. Our objective was to investigate whether attitudes regarding elective single embryo transfer (eSET) and multifetal reduction are associated with geographic region.

DESIGN:

Retrospective descriptive analysis of cross-sectional online survey.

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