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Increased Scrutiny of NGS Profiles / Ranking Does Not Improve eSet Implantation of Euploid Blastocysts: a Randomized Comparative Trial

Increased Scrutiny of NGS Profiles / Ranking Does Not Improve eSet Implantation of Euploid Blastocysts: a Randomized Comparative Trial

Study question:

Can Next Generation sequencing (NGS) profile ranking of euploid embryos better predict eSET implantation potential of top quality blastocysts in contrast to morphological grading alone.

Summary answer:

When blastocysts are both top quality and euploid, the lack of noise on a NGS profile adds no benefit for eSET compared to embryo grading.

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Euploid Rate of Embryos Derived From Aspirated and Ejaculated Sperm

Euploid Rate of Embryos Derived From Aspirated and Ejaculated Sperm

Objective:

To determine the euploid rate relationship between aspirated and ejaculated sperm-sourced embryos

Design:

Retrospective study

Materials and Methods:

Trophectoderm biopsy and PGS screening were performed on Day 5, 6 and 7 embryos were tested over a 2 year period. Biopsied embryos were segregated into based on sperm source: Percutaneous Epididymal Sperm Aspiration (PESA),

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An initial review of next generation screening: A new service provider for comprehensive chromosomal screening (CCS) by next generation sequencing (NGS)

An initial review of next generation screening: A new service provider for comprehensive chromosomal screening (CCS) by next generation sequencing (NGS)

Objective:

To review the initial results of embryo chromosomal competency and pregnancy success generated from one IVF laboratory by a new preimplantation genetic screening (PGS) service provider, Ovation Fertility Genetics.

Design:

Retrospective analysis in a private genetics laboratory.

Materials and Methods:

1861 blastocyst stage embryos underwent trophectoderm biopsy and subsequent comprehensive chromosomal screening (CCS) by next generation sequencing (NGS) over a 17-month period.

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Global multicenter randomized controlled trial comparing single embryo transfer with embryo selected by preimplantation genetic screening using next-generation sequencing versus morphologic assessment

Global multicenter randomized controlled trial comparing single embryo transfer with embryo selected by preimplantation genetic screening using next-generation sequencing versus morphologic assessment

OBJECTIVE:

The aim of this study was to assess the potential benefit of preimplantation genetic screening (PGS) across multiple international clinical sites and testing laboratories.

DESIGN:

Blinded, multicenter, randomized, controlled trial of women undergoing IVF with frozen embryo transfer: Control arm, embryo selection based on morphology; intervention arm, embryo selection by next-generation sequencing (NGS)-based PGS.

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The value in retaining non-pronuclear (0PN) zygotes for extended culture

The value in retaining non-pronuclear (0PN) zygotes for extended culture

Objective:

To determine the occurrence and ploidy status of usable embryos derived from oocytes not displaying two pronuclei (0PN) at the time of fertilization assessment.

Design:

Retrospective study in a private in vitro fertilization laboratory.

Materials and Methods:

A total of 3,370 blastocysts were identified as being morphologically suitable for fresh embryo transfer,

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Endometrial receptivity and pregnancy rates are higher after 7 days of progesterone in medicated FET cycles

Endometrial receptivity and pregnancy rates are higher after 7 days of progesterone in medicated FET cycles

OBJECTIVE:

To determine if Endometrial Receptivity Analysis (ERA) testing will improve implantation and pregnancy rates in patients undergoing medicated frozen embryo transfer (FET) cycles.

DESIGN:

Retrospective study in a large private practice fertility clinic.

MATERIALS AND METHODS:

We included all patients who had one or more ERA tests (Igenomix) in our clinic from 1/2016 to 5/2017.

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Examining the luteal placental shift in pregnancy after frozen embryo transfer

Examining the luteal placental shift in pregnancy after frozen embryo transfer

OBJECTIVE:

The purpose of this study is to attempt to define the timing of the luteal-placental shift using pregnancies resulting from frozen embryo transfer (FET) as a model.

DESIGN:

Retrospective chart review.

MATERIALS AND METHODS:

We identified 262 women who conceived following FET between December, 2013-December, 2016. Patients received oral estradiol (E2) for endometrial stimulation.

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Day 5, 6, and 7 blastocyst ploidy status stratified by patient age

Day 5, 6, and 7 blastocyst ploidy status stratified by patient age

OBJECTIVE:

To determine if a relationship of ploidy status in day 5, 6, and 7 blastocysts exists amongst patient age groups.

DESIGN:

Retrospective study in a private in vitro fertilization laboratory.

MATERIALS AND METHODS:

Blastocysts underwent trophectoderm biopsy and subsequent comprehensive chromosomal screening over the course of 3 years. PGS results were retrospectively compared to the day of trophectoderm biopsy and stratified by patient age.

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Blastocyst morphology is a poor indicator of euploid status

Blastocyst morphology is a poor indicator of euploid status

OBJECTIVE:

To evaluate the importance of blastocyst morphology in known euploid blastocysts.

DESIGN:

Retrospective study in a private assisted reproductive technology program.

MATERIALS AND METHODS:

The euploid status of blastocysts considered to be of marginal morphology was compared to that of good morphology blastocysts following trophectoderm biopsy and preimplantation genetic screening (PGS).

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Then and now: are past IVF experiences associated with current preferences regarding elective single embryo transfer?

Then and now: are past IVF experiences associated with current preferences regarding elective single embryo transfer?

OBJECTIVE:

Previous experiences with fertility treatment and pregnancy outcomes may influence the likelihood of a patient choosing elective single embryo transfer (eSET). Our objective was to investigate whether desire to undergo eSET is associated with previous IVF experiences.

DESIGN:

Retrospective descriptive analysis of online cross-sectional survey.

MATERIALS AND METHODS:

An anonymous survey regarding eSET preferences and experiences was distributed through social media over a five-week span in 2014.

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Demographic characteristics associated with elective single embryo transfer in IVF: who chooses just one?

Demographic characteristics associated with elective single embryo transfer in IVF: who chooses just one?

OBJECTIVE:

Younger patient age has been found in previous IVF studies to be associated both with desire for twins and the choice of single embryo transfer; we sought to examine this and other demographic and geographic parameters in relation to elective single embryo transfer (eSET).

DESIGN:

Descriptive analysis of online survey results from a cross-sectional sample of U.S.

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